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KMID : 0380620170490060668
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Korean Journal of Food Science and Technology
2017 Volume.49 No. 6 p.668 ~ p.675
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Protective effects of Aruncus dioicus var. kamtschaticus extract against hyperglycemic-induced neurotoxicity
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Park Su-Bin
Lee Uk
Kang Jin-Yong
Kim Jong-Min
Park Seon-Kyeong
Park Sang-Hyun
Choi Sung-Gil
Heo Ho-Jin
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Abstract
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To assess the physiological effects of Aruncus dioicus var. kamtschaticus extract on cytoxicity of a neuronal cell line, antioxidant activity, and neuroprotection against intensive glucose-induced oxidative stress were quantitated. Compared to the other fractions, the ethyl acetate fraction of Aruncus dioicus var. kamtschaticus (EFAD) showed the highest total phenolics and flavonoids. The 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay and malondialdehyde inhibitory effect test confirmed the superior antioxidant activity of EFAD. Moreover, EFAD also decreased the intracellular ROS level and suppressed neuronal cell death against intensive glucose- or H2O2-induced oxidative stress. Additionally, assessment of α-glucosidase and acetylcholinesterase inhibitory activities revealed that EFAD was an effective inhibitor of α-glucosidase and acetylcholinesterase. Finally, high-performance liquid chromatography analysis identified caffeic acid as the main ingredient of EFAD. Overall, these results suggest that the EFAD is a good natural source of biological compounds that counteract hyperglycemic neuronal defects.
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KEYWORD
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antioxidant activity, Aruncus dioicus var. kamtschaticus, caffeic acid, hyperglycemic neurotoxicity
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